import Layout from '../../../../../components/Layout/Layout.js'; import NextLink from 'next/link'; import NextImage from 'next/image'; import Divider from '@mui/material/Divider';

import Alert from '@mui/material/Alert'; import AlertTitle from '@mui/material/AlertTitle';

import MuiLink from '../../../../../src/Link.js';

import Box from '@mui/material/Box'; import Grid from '@mui/material/Grid'; import Container from '@mui/material/Container'; import NewsTemplate from '../../../../../components/PageTemplate_newsletter.js'; import Quote from '../../../../../components/QuoteStatement.js'; import YoutubeVideoPlayer from '../../../../../components/YoutubePlayer.js';

import WebinarSignUp from '../../../../../components/FormWebinarSignUp.js';

import ImpactCard from '../../../impactCard.js'; import MoreProjects from '../../../../../components/MoreProjects.js'; export const arrayz = Array.from({ length: 12 }, (v, k) => k); export const shuffledz = arrayz.sort(() => 0.5 - Math.random()); export const indicesz = shuffledz.slice(0, 3);

export const code = ''; export const title = ''; export const fullname = ''; export const schoolname = ''; export const paper_link = ''; export const poster_link = ''; export const video_link = '';

export const frontMatter = { title: ${title}, description: By: ${fullname}, ${schoolname}, author: ${fullname}, };

export const full_name = fullname.replace(/\s+/g, '-').toLowerCase(); export const titleImage = https://elio-email-s3bkt.s3.us-west-1.amazonaws.com/blogs/24/${code}-poster.jpg; export const avatarImage = /images/avatar/24/${full_name}.jpg;

<Container sx={{ pt: 1, textAlign: 'center' }}> (Click on the poster to enlarge)

<Container maxWidth='md' sx={{ py: 1}} >

<Box sx={{ maxWidth: '720px', borderRadius: '0.7rem', textAlign: 'center', //background: '#fff', border: '1px solid', fontSize: '1.1rem' }}>

<Grid item xs={12} md={3}>
  <b>Quick Links</b>:
</Grid>

<Grid item xs={4} md={3}>
  <MuiLink href='#video'>
      Video Presentation
  </MuiLink>
</Grid>

<Grid item xs={4} md={3}>
  <MuiLink href='#impact'>
      Impact Statement
  </MuiLink>
</Grid>

<Grid item xs={4} md={3}>
  <MuiLink href='#paper'>
      White Paper Report
  </MuiLink>
</Grid>

This project explores achondroplasia, a form of skeletal dysplasia or dwarfism caused by genetic mutations. Affecting approximately 1 in 15,000 individuals, achondroplasia is characterized by disproportionate dwarfism, where individuals have an average-sized torso and short limbs. The condition is primarily caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene, leading to abnormal bone growth due to impaired chondrocyte proliferation. Most cases arise from a spontaneous germline mutation, although achondroplasia can be inherited as an autosomal dominant trait. Diagnosis typically occurs at birth or in late pregnancy through genetic testing and radiographs. The condition presents several health challenges, including potential neurological impairments caused by bone growth issues compressing key nervous system structures. Complications such as spinal stenosis, foramen magnum stenosis, and hydrocephalus can arise, requiring medical intervention. Treatment advancements include the use of Voxzogo (vosoritide), a therapeutic drug that targets FGFR3 signaling to promote bone growth. While effective, Voxzogo presents challenges like high cost and side effects. Surgical interventions may also be necessary for managing symptoms and complications. Ongoing research aims to enhance treatment options, focusing on prenatal therapies and exploring alternative approaches to inhibit FGFR3 signaling. Achondroplasia research has made significant strides, with future developments expected to improve accessibility and efficacy of treatments.

<Container sx={{ py: 1, textAlign: 'center' }}> <NextImage src={https://elio-email-s3bkt.s3.us-west-1.amazonaws.com/blogs/24/${code}-fig.jpg} width="250" height="185" objectFit="cover" /> SOME_TEXT_CAPTION (Figure representation created by the author: {fullname})

<Box sx={{ maxWidth: '720px', mx: 'auto', my: 1, borderRadius: '2rem', boxShadow: '5rem', }}

<Container sx={{ pt: 1, textAlign: 'center' }}> <NextImage src={https://elio-email-s3bkt.s3.us-west-1.amazonaws.com/blogs/24/${code}-paper.jpg} width="350" height="500" objectFit="cover" /> (Click to view the full report)

_By: {fullname}_

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of Elio Academy.

{' '}

export default ({ children }) => ( <NewsTemplate {...frontMatter}>{children} );