Targeting Glucose Metabolism & Transport for Cancer Treatment
By: Ishita Yadav, Amador Valley High School
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Summary
This project explores how cancer cells alter their metabolism to support uncontrolled growth and proliferation. Unlike normal cells, cancer cells rely heavily on glycolysis, even in the presence of oxygen—a phenomenon known as the Warburg Effect. This altered metabolism increases glucose uptake and fermentation into lactate, supporting rapid tumor growth. The study highlights the potential of targeting glucose metabolism as a therapeutic strategy in cancer treatment. Current treatments, such as ivosidenib and enasidenib, target metabolic pathways in cancer cells, and ongoing research focuses on developing more effective drugs and combining them with other therapies to improve cancer treatment outcomes.
Video Presentation
Impact Statement
I am Ishita Yadav, a junior at Amador Valley High School, CA. I learned about precision medicine, which I thought is very interesting, and is growing day by day, but also how it's impacting lives as well. I also learned about cancer, and how dangerous it is, and the genetics component of it. My project is based about cancer cell, how it makes it's own energy compared to a normal cell would. Also, my project describes the warburg effect, which is the way cancer cell makes it's energy, and explained how that is different than cellular respiration. The poster and the research we had to do helped me use different sources that I don't think I would've ever come across such as NCBI, Mayo Clinic etc. It also allowed me to go into in-depth projects allowing me to get a greater insight into ongoing projects. Through this program, and with the guidance of my mentor I was able to learn more about this fabulous topic!
Report White Paper
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_By: Ishita Yadav_
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of Elio Academy.
